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Ongoing beta cell death in type 1 diabetes (T1D) can be detected using biomarkers selectively discharged by dying beta cells vegas golden knights background into plasma.microRNA-375 (miR-375) ranks among the top biomarkers based on studies in animal models and human islet transplantation.Our objective was to identify additional microRNAs that are c
Abstract Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown.Here, we induce chromosome mis-segregation in non-transformed RPE1-hTERT cells and derive multiple stable clones with various degrees of aneuploidy.We perform a systematic genomic, transcriptomic a
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